Sources scientifiques

  1. Aspartame and Other Sweeteners in Food

    FDA · 2024

    U.S. Food and Drug Administration

    https://www.fda.gov/food/food-additives-petitions/aspartame-and-other-sweeteners-food
  2. Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort

    NIH (PMC) · 1 septembre 2023

    Debras C., Deschasaux-Tanguy M., Chazelas E., Sellem L., Druesne-Pecollo N., Esseddik Y., et al.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465821/
  3. The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

    Nature · 1 mars 2023

    Zani F., Blagih J., Gruber T., et al.

    https://doi.org/10.1038/s41586-023-05801-6
  4. Newborns from Mothers Who Intensely Consumed Sucralose during Pregnancy Are Heavier and Exhibit Markers of Metabolic Alteration and Low-Grade Systemic Inflammation: A Cross-Sectional, Prospective Study

    MDPI (Biomedicines) · 21 février 2023

    Aguayo-Guerrero JA., Méndez-García LA., Manjarrez-Reyna AN., et al.

    https://pubmed.ncbi.nlm.nih.gov/36979631/
  5. Biological Assessment of Stevioside and Sucralose as Sucrose Substitutes for Diabetics on STZ-Induced Diabetes in Rats

    MDPI (Molecules) · 2023

    Barakat H., Al-Roug K., Algonaiman R., et al.

    https://doi.org/10.3390/molecules28030940
  6. Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort

    BMJ · 1 septembre 2022

    Debras C., Chazelas E., Sellem L., Porcher R., Druesne-Pecollo N., Esseddik Y., et al.

    https://doi.org/10.1136/bmj-2022-071204
  7. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

    Cell · 1 septembre 2022

    Suez J., Cohen Y., Valdés-Mas R., Mor U., Dori-Bachash M., Federici S., et al.

    https://pubmed.ncbi.nlm.nih.gov/35987213/
  8. Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study

    PLOS · 24 mars 2022

    Debras C., Chazelas E., Srour B., Druesne-Pecollo N., Esseddik Y., et al.

    https://doi.org/10.1371/journal.pmed.1003950
  9. Low Dose of Sucralose Alter Gut Microbiome in Mice

    Frontiers · 1 mars 2022

    Zheng Z., Xiao Y., Ma L., Lyu W., Peng H., Wang X., et al.

    https://doi.org/10.3389/fnut.2022.848392
  10. Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3

    Frontiers · 1 mars 2022

    Wu H. T., Lin C. H., Pai H. L., Chen Y. C., Cheng K. P., Kuo H. Y., et al.

    https://doi.org/10.3389/fnut.2022.823723
  11. Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults

    MDPI (Microorganisms) · 1 février 2022

    Méndez-García L. A., Bueno-Hernández N., Cid-Soto M. A., et al.

    https://doi.org/10.3390/microorganisms10020434
  12. Low Doses of Sucralose Alter Fecal Microbiota in High-Fat Diet-Induced Obese Rats

    Frontiers · 1 novembre 2021

    Zhang M., Chen J., Yang M., Qian C., Liu Y., Qi Y., et al.

    https://doi.org/10.3389/fnut.2021.787055
  13. Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells

    Nature (International Journal of Obesity) · 1 octobre 2020

    Azad M. B., Archibald A., Tomczyk M. M., et al.

    https://doi.org/10.1038/s41366-020-0575-x
  14. Sucralose causes non-selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8/APTX/EID1 genes: An in vitro/in silico study

    Wiley (CEPP) · 1 octobre 2020

    Pasqualli T., E Chaves P. E., da Veiga Pereira L., et al.

    https://doi.org/10.1111/1440-1681.13362
  15. The impact of food additives, artificial sweeteners and domestic hygiene products on the human gut microbiome and its fibre fermentation capacity

    Springer (European Journal of Nutrition) · 1 octobre 2020

    Gerasimidis K., Bryden K., Chen X., et al.

    https://doi.org/10.1007/s00394-019-02161-8
  16. Consumption of Diet Soda Sweetened with Sucralose and Acesulfame-Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity

    Wiley (Molecular Nutrition & Food Research) · 1 juin 2020

    Sylvetsky A. C., Sen S., Merkel P., et al.

    https://doi.org/10.1002/mnfr.201901166
  17. Artificial sweeteners impair endothelial vascular reactivity: Preliminary results in rodents

    NMCD · 1 mai 2020

    Risdon S., Meyer G., Marziou A., Riva C., Roustit M., Walther G.

    https://doi.org/10.1016/j.numecd.2020.01.014
  18. Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial

    BioMed Central (Nutrition Journal) · 1 avril 2020

    Bueno-Hernández N., Esquivel-Velázquez M., Alcántara-Suárez R., et al.

    https://doi.org/10.1186/s12937-020-00549-5
  19. Maternal sucralose intake alters gut microbiota of offspring and exacerbates hepatic steatosis in adulthood

    Taylor & Francis (Gut Microbes) · 2020

    Dai X., Guo Z., Chen D., Li L., Song X., Liu T., et al.

    https://pubmed.ncbi.nlm.nih.gov/32228300/
  20. Maternal exposure to non-nutritive sweeteners impacts progeny's metabolism and microbiome

    Frontiers · 2019

    Olivier-Van Stichelen S., Rother K. I., Hanover J. A.

    https://doi.org/10.3389/fmicb.2019.01360
  21. Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial

    Oxford Academic (AJCN) · 1 septembre 2018

    Romo-Romo A., Aguilar-Salinas C. A., Brito-Córdova G. X., et al.

    https://doi.org/10.1093/ajcn/nqy152
  22. Intestinal metabolism and bioaccumulation of sucralose in adipose tissue in the rat

    Taylor & Francis (JTEH) · 1 août 2018

    Bornemann V., Werness S. C., Buslinger L., Schiffman S. S.

    https://doi.org/10.1080/15287394.2018.1502560
  23. Type of sweet flavour carrier affects thyroid axis activity in male rats

    Springer (European Journal of Nutrition) · 1 mars 2018

    Pałkowska-Goździk E., Bigos A., Rosołowska-Huszcz D.

    https://doi.org/10.1007/s00394-016-1367-x
  24. Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, double-blind, placebo-controlled trial

    Nutrition · 2018

    Lertrit A., Srimachai S., Saetung S., et al.

    https://doi.org/10.1016/j.nut.2018.04.001
  25. Critical review of the current literature on the safety of sucralose

    ScienceDirect (FCT) · 1 juillet 2017

    Magnuson B. A., Roberts A., Nestmann E. R.

    https://pubmed.ncbi.nlm.nih.gov/28558975/
  26. Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice

    Frontiers · 1 juillet 2017

    Bian X., Chi L., Gao B., Tu P., Ru H., Lu K.

    https://doi.org/10.3389/fphys.2017.00487
  27. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies

    CMAJ (via NIH/PubMed) · 1 juillet 2017

    Azad M. B., et al.

    https://www.ncbi.nlm.nih.gov/pubmed/28716847
  28. Effects of low-dose non-caloric sweetener consumption on gut microbiota in mice

    MDPI (Nutrients) · 1 juin 2017

    Uebanso T., Ohnishi A., Kitayama R., et al.

    https://doi.org/10.3390/nu9060560
  29. Statement on the validity of the conclusions of a mouse carcinogenicity study on sucralose (E 955) performed by the Ramazzini Institute

    EFSA · 1 mai 2017

    EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)

    https://doi.org/10.2903/j.efsa.2017.4784
  30. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice

    Taylor & Francis (IJOEH) · 2016

    Soffritti M., Padovani M., Tibaldi E., et al.

    https://doi.org/10.1016/j.fct.2017.05.047
  31. Avis du 19 novembre 2014 révisé le 9 janvier 2015 relatif à l'évaluation des bénéfices et des risques nutritionnels des édulcorants intenses

    ANSES · 9 janvier 2015

    Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail

    https://www.anses.fr/fr/system/files/NUT2011sa0161Ra.pdf
  32. Artificial sweeteners induce glucose intolerance by altering the gut microbiota

    Nature (via NIH/PubMed) · 1 octobre 2014

    Suez J., et al.

    https://pubmed.ncbi.nlm.nih.gov/25231862/
  33. Sucralose affects glycemic and hormonal responses to an oral glucose load

    Diabetes Care · 1 septembre 2013

    Pepino M. Y., Tiemann C. D., Patterson B. W., Wice B. M., Klein S.

    https://doi.org/10.2337/dc12-2221
  34. Studies on glucose homeostasis in healthy humans and diabetic volunteers. In: Opinion of the Scientific Committee on Food on Sucralose

    Commission Européenne · 7 septembre 2000

    Scientific Committee on Food (SCF)

    https://food.ec.europa.eu/system/files/2020-12/sci-com_scf_out68_en.pdf