[{"data":1,"prerenderedAt":202},["ShallowReactive",2],{"additive-detail:e960":3},{"articlePublished":4,"id":5,"code":6,"name":7,"slug":8,"type":9,"rating":10,"summary":11,"typeDescription":12,"risks":13,"bibliography":157,"hasDetail":4},true,"b2db8d84-1505-4860-a2a9-1efae463ce1a","E960a","Glycosides de stéviol issus de stévia","e960","Édulcorant",2,"Les glycosides de stéviol (E960a) remplacent le sucre sans apport calorique. EFSA et JECFA ont fixé une DJA de 4 mg\u002Fkg p.c.\u002Fj (équivalents stéviol) ; l'ANSES souligne l'absence de bénéfice nutritionnel démontré des édulcorants intensifs pour le contrôle du poids. Des études expérimentales rapportent des effets possibles sur le microbiote, la tolérance au glucose et le métabolisme, tandis que des cohortes NutriNet-Santé associent les édulcorants intensifs à des risques cardiovasculaires et de cancer, avec une contribution propre de la stévia souvent moins clairement isolée que pour d'autres édulcorants.","Édulcorant intense extrait des feuilles de Stevia rebaudiana (glycosides de stéviol), sans calories.",[14,69,86,107,134],{"risk":15,"explanation":19,"sources":20},{"slug":16,"label":17,"icon":18},"microbiote","Perturbation du microbiote","biotech","Les glycosides de stéviol sont hydrolysés par le microbiote colique en stéviol. Plusieurs études expérimentales (Nettleton, Becker, Wang, Ruiz-Ojeda) et des travaux sur les édulcorants non nutritifs (Suez, Gerasimidis) décrivent des modifications du microbiote et, parfois, des effets intergénérationnels après exposition maternelle.",[21,28,35,42,48,55,62],{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},"b960a001-0001-4001-8001-000000000009","Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance","Cell","Suez J., Cohen Y., Valdés-Mas R., Mor U., Dori-Bachash M., Federici S., et al.","2022-08-19","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.cell.2022.07.016",{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},"b960a001-0001-4001-8001-000000000012","A metagenomics investigation of intergenerational effects of non-nutritive sweeteners on gut microbiome","Frontiers in Nutrition","Wang W., Nettleton J. E., Gänzle M. G., Reimer R. A.","2022-01-01","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffnut.2021.795848",{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},"b960a001-0001-4001-8001-000000000016","Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their offspring","Gut","Nettleton J. E., Cho N. A., Klancic T., Nicolucci A. C., Shearer J., Borgland S. L., et al.","2020-10-01","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fgutjnl-2018-317571",{"id":43,"title":44,"publisher":45,"authors":46,"publishedOn":40,"url":47},"b960a001-0001-4001-8001-000000000014","The impact of food additives, artificial sweeteners and domestic hygiene products on the human gut microbiome and its fibre fermentation capacity","European Journal of Nutrition","Gerasimidis K., Bryden K., Chen X., et al.","https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00394-019-02161-8",{"id":49,"title":50,"publisher":51,"authors":52,"publishedOn":53,"url":54},"b960a001-0001-4001-8001-000000000015","Effect of stevia on the gut microbiota and glucose tolerance in a murine model of diet-induced obesity","FEMS Microbiology Ecology","Becker S. L., Chiang E., Plantinga A., Carey H. V., Suen G., Swoap S. J.","2020-06-01","https:\u002F\u002Fdoi.org\u002F10.1093\u002Ffemsec\u002Ffiaa079",{"id":56,"title":57,"publisher":58,"authors":59,"publishedOn":60,"url":61},"b960a001-0001-4001-8001-000000000019","Low-Dose Stevia (Rebaudioside A) Consumption Perturbs Gut Microbiota and the Mesolimbic Dopamine Reward System","Nutrients","Nettleton J. E., Klancic T., Schick A., Choo A. C., Shearer J., Borgland S. L., et al.","2019-06-01","https:\u002F\u002Fdoi.org\u002F10.3390\u002Fnu11061248",{"id":63,"title":64,"publisher":65,"authors":66,"publishedOn":67,"url":68},"b960a001-0001-4001-8001-000000000018","Effects of sweeteners on the gut microbiota: a review of experimental studies and clinical trials","Advances in Nutrition","Ruiz-Ojeda F. J., Plaza-Díaz J., Sáez-Lara M. J., Gil A.","2019-01-01","https:\u002F\u002Fdoi.org\u002F10.1093\u002Fadvances\u002Fnmy037",{"risk":70,"explanation":74,"sources":75},{"slug":71,"label":72,"icon":73},"diabete-type-2","Diabète de type 2","bloodtype","Malgré l'absence de calories, des travaux humains (Suez et al.) et animaux (Tsan\u002Fstevia, Nettleton) suggèrent que certains édulcorants non nutritifs, dont la stévia selon les protocoles, peuvent altérer la tolérance au glucose ou le métabolisme énergétique.",[76,83,84,85],{"id":77,"title":78,"publisher":79,"authors":80,"publishedOn":81,"url":82},"b960a001-0001-4001-8001-000000000011","Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats","JCI Insight","Tsan L., Chometton S., Hayes A. M. R., Klug M. E., Zuo Y., Sun S., et al.","2022-09-13","https:\u002F\u002Fdoi.org\u002F10.1172\u002Fjci.insight.157714",{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},{"id":49,"title":50,"publisher":51,"authors":52,"publishedOn":53,"url":54},{"risk":87,"explanation":91,"sources":92},{"slug":88,"label":89,"icon":90},"maladies-cardiovasculaires","Maladies cardiovasculaires","cardiology","La cohorte NutriNet-Santé (2022) a associé la consommation d'édulcorants artificiels à un risque cardiovasculaire accru. La part spécifique des glycosides de stéviol dans ces résultats est moins clairement isolée que pour d'autres édulcorants, mais le signal de classe justifie la prudence.",[93,100],{"id":94,"title":95,"publisher":96,"authors":97,"publishedOn":98,"url":99},"b960a001-0001-4001-8001-000000000007","Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort","BMJ","Debras C., Chazelas E., Sellem L., Porcher R., Druesne-Pecollo N., Esseddik Y., et al.","2022-09-07","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmj-2022-071204",{"id":101,"title":102,"publisher":103,"authors":104,"publishedOn":105,"url":106},"b960a001-0001-4001-8001-000000000006","Avis du 19 novembre 2014 révisé le 9 janvier 2015 relatif à l'évaluation des bénéfices et des risques nutritionnels des édulcorants intenses (Saisine n°2011-SA-0161)","ANSES","Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail","2015-01-09","https:\u002F\u002Fwww.anses.fr\u002Ffr\u002Fsystem\u002Ffiles\u002FNUT2011sa0161Ra.pdf",{"risk":108,"explanation":112,"sources":113},{"slug":109,"label":110,"icon":111},"cancer-suspecte","Cancérogène suspecté","oncology","NutriNet-Santé (2022) a observé une association entre édulcorants artificiels et risque de cancer. Comme pour le risque cardiovasculaire, la contribution propre de la stévia reste discutée ; les avis EFSA sur les glycosides de stéviol ne concluent pas à un risque cancérogène aux usages autorisés.",[114,121,128],{"id":115,"title":116,"publisher":117,"authors":118,"publishedOn":119,"url":120},"b960a001-0001-4001-8001-000000000005","Scientific opinion on the extension of the authorisation of use of the food additive steviol glycosides (E 960a–d) and the modification of the acceptable daily intake (ADI) for steviol","EFSA Journal","EFSA Panel on Food Additives and Flavourings (FAF)","2024-10-24","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2024.9045",{"id":122,"title":123,"publisher":124,"authors":125,"publishedOn":126,"url":127},"b960a001-0001-4001-8001-000000000008","Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study","PLoS Medicine","Debras C., Chazelas E., Srour B., Druesne-Pecollo N., Esseddik Y., et al.","2022-03-24","https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pmed.1003950",{"id":129,"title":130,"publisher":117,"authors":131,"publishedOn":132,"url":133},"b960a001-0001-4001-8001-000000000001","Scientific Opinion on the safety of steviol glycosides for the proposed uses as a food additive","EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)","2010-04-14","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2010.1537",{"risk":135,"explanation":139,"sources":140},{"slug":136,"label":137,"icon":138},"troubles-metaboliques","Troubles du métabolisme","metabolism","Des modèles animaux relient une exposition précoce ou maternelle à la stévia (parfois associée à un régime obésogène) à des altérations métaboliques, du système de récompense et, dans certains cas, de la cognition chez la descendance.",[141,148,149,155,156],{"id":142,"title":143,"publisher":144,"authors":145,"publishedOn":146,"url":147},"b960a001-0001-4001-8001-000000000010","Effect of Long-Term Intake of Maltitol and Non-Nutritive Sweeteners on Metabolic Health and Cognition in Adult Male Rats","Journal of Medicinal Food","Morales-Ríos E. I., García-Medrano J., Briones-Aranda A., Gómez-Pliego R., Espinosa-Raya J.","2022-11-01","https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpmc\u002Farticles\u002FPMC9680331\u002F",{"id":77,"title":78,"publisher":79,"authors":80,"publishedOn":81,"url":82},{"id":150,"title":151,"publisher":152,"authors":153,"publishedOn":33,"url":154},"b960a001-0001-4001-8001-000000000013","Maternal sweeteners intake modulates gut microbiota and exacerbates learning and memory processes in adult male offspring","Frontiers in Pediatrics","de la Garza A. L., Ramos-Delgado A., Martinez-Torres A. M., et al.","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffped.2021.740407",{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},{"id":56,"title":57,"publisher":58,"authors":59,"publishedOn":60,"url":61},[158,159,160,161,162,163,164,165,166,167,168,169,176,177,178,185,190,191,196,201],{"id":115,"title":116,"publisher":117,"authors":118,"publishedOn":119,"url":120},{"id":142,"title":143,"publisher":144,"authors":145,"publishedOn":146,"url":147},{"id":77,"title":78,"publisher":79,"authors":80,"publishedOn":81,"url":82},{"id":94,"title":95,"publisher":96,"authors":97,"publishedOn":98,"url":99},{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},{"id":122,"title":123,"publisher":124,"authors":125,"publishedOn":126,"url":127},{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},{"id":150,"title":151,"publisher":152,"authors":153,"publishedOn":33,"url":154},{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},{"id":43,"title":44,"publisher":45,"authors":46,"publishedOn":40,"url":47},{"id":49,"title":50,"publisher":51,"authors":52,"publishedOn":53,"url":54},{"id":170,"title":171,"publisher":172,"authors":173,"publishedOn":174,"url":175},"b960a001-0001-4001-8001-000000000017","Stevia, the active principle of the stevia sweetener, causes a reduction of the cells of the immunological system even consumed in low concentrations","Immunopharmacology and Immunotoxicology","Pasqualli T., Chaves P. E. E., Pereira L. V., et al.","2020-01-01","https:\u002F\u002Fdoi.org\u002F10.1080\u002F08923973.2020.1811309",{"id":56,"title":57,"publisher":58,"authors":59,"publishedOn":60,"url":61},{"id":63,"title":64,"publisher":65,"authors":66,"publishedOn":67,"url":68},{"id":179,"title":180,"publisher":181,"authors":182,"publishedOn":183,"url":184},"b960a001-0001-4001-8001-000000000020","Sweeteners as food additives in the XXI century: A review of what is known, and what is to come","Food and Chemical Toxicology","Carocho M., Morales P., Ferreira I. C. F. R.","2017-09-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.fct.2017.06.046",{"id":186,"title":187,"publisher":117,"authors":131,"publishedOn":188,"url":189},"b960a001-0001-4001-8001-000000000004","Scientific Opinion on the extension of use of steviol glycosides (E 960) as a food additive","2015-06-01","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2015.4146",{"id":101,"title":102,"publisher":103,"authors":104,"publishedOn":105,"url":106},{"id":192,"title":193,"publisher":117,"authors":131,"publishedOn":194,"url":195},"b960a001-0001-4001-8001-000000000003","Scientific Opinion on the revised exposure assessment of steviol glycosides (E 960) for the proposed uses as a food additive","2014-05-01","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2014.3639",{"id":197,"title":198,"publisher":117,"authors":131,"publishedOn":199,"url":200},"b960a001-0001-4001-8001-000000000002","Revised exposure assessment for steviol glycosides for the proposed uses as a food additive","2011-01-19","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2011.1972",{"id":129,"title":130,"publisher":117,"authors":131,"publishedOn":132,"url":133},1789814238950]