[{"data":1,"prerenderedAt":325},["ShallowReactive",2],{"additive-sources:e955":3},{"articlePublished":4,"id":5,"code":6,"name":7,"slug":8,"type":9,"rating":10,"summary":11,"typeDescription":12,"risks":13,"bibliography":267,"hasDetail":4},true,"beb8640f-22ca-4c5a-bf05-e69dfdb66d60","E955","Sucralose","e955","Édulcorant",3,"Cet édulcorant artificiel serait associé à une altération de la réponse glycémique, à une dysbiose intestinale ainsi qu'à des risques accrus de stéatose hépatique et de troubles immunitaires. Plusieurs études soulignent qu'au lieu d'aider à réguler le poids, sa consommation régulière pourrait perturber le métabolisme et augmenter les risques de surpoids et de maladies chroniques.","Édulcorant chloré dérivé du saccharose, stable à la chaleur.",[14,77,120,153,179,207,254],{"risk":15,"explanation":19,"sources":20},{"slug":16,"label":17,"icon":18},"diabete-type-2","Diabète de type 2","bloodtype","Le sucralose serait associé à un dérèglement de la glycémie, une hausse de l'insuline et une baisse de la sensibilité à l'insuline chez l'humain et l'animal, malgré l'absence de calories.",[21,28,35,42,49,56,63,70],{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},"b9550001-0001-4001-8001-000000000008","Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort","NIH (PMC)","Debras C., Deschasaux-Tanguy M., Chazelas E., Sellem L., Druesne-Pecollo N., Esseddik Y., et al.","2023-09-01","https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpmc\u002Farticles\u002FPMC10465821\u002F",{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},"b9550001-0001-4001-8001-000000000011","Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance","Cell","Suez J., Cohen Y., Valdés-Mas R., Mor U., Dori-Bachash M., Federici S., et al.","2022-09-01","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F35987213\u002F",{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},"b9550001-0001-4001-8001-000000000012","Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults","MDPI (Microorganisms)","Méndez-García L. A., Bueno-Hernández N., Cid-Soto M. A., et al.","2022-02-01","https:\u002F\u002Fdoi.org\u002F10.3390\u002Fmicroorganisms10020434",{"id":43,"title":44,"publisher":45,"authors":46,"publishedOn":47,"url":48},"b9550001-0001-4001-8001-000000000020","Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial","BioMed Central (Nutrition Journal)","Bueno-Hernández N., Esquivel-Velázquez M., Alcántara-Suárez R., et al.","2020-04-01","https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12937-020-00549-5",{"id":50,"title":51,"publisher":52,"authors":53,"publishedOn":54,"url":55},"b9550001-0001-4001-8001-000000000024","Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial","Oxford Academic (AJCN)","Romo-Romo A., Aguilar-Salinas C. A., Brito-Córdova G. X., et al.","2018-09-01","https:\u002F\u002Fdoi.org\u002F10.1093\u002Fajcn\u002Fnqy152",{"id":57,"title":58,"publisher":59,"authors":60,"publishedOn":61,"url":62},"b9550001-0001-4001-8001-000000000026","Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, double-blind, placebo-controlled trial","Nutrition","Lertrit A., Srimachai S., Saetung S., et al.","2018-01-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.nut.2018.04.001",{"id":64,"title":65,"publisher":66,"authors":67,"publishedOn":68,"url":69},"b9550001-0001-4001-8001-000000000033","Artificial sweeteners induce glucose intolerance by altering the gut microbiota","Nature (via NIH\u002FPubMed)","Suez J., et al.","2014-10-01","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F25231862\u002F",{"id":71,"title":72,"publisher":73,"authors":74,"publishedOn":75,"url":76},"b9550001-0001-4001-8001-000000000034","Sucralose affects glycemic and hormonal responses to an oral glucose load","Diabetes Care","Pepino M. Y., Tiemann C. D., Patterson B. W., Wice B. M., Klein S.","2013-09-01","https:\u002F\u002Fdoi.org\u002F10.2337\u002Fdc12-2221",{"risk":78,"explanation":82,"sources":83},{"slug":79,"label":80,"icon":81},"microbiote","Perturbation du microbiote","biotech","Plusieurs études rapportent une perturbation profonde du microbiote intestinal (dysbiose) après consommation de sucralose, avec des effets sur la tolérance au glucose.",[84,85,92,93,99,106,112,119],{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},{"id":86,"title":87,"publisher":88,"authors":89,"publishedOn":90,"url":91},"b9550001-0001-4001-8001-000000000013","Low Dose of Sucralose Alter Gut Microbiome in Mice","Frontiers","Zheng Z., Xiao Y., Ma L., Lyu W., Peng H., Wang X., et al.","2022-03-01","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffnut.2022.848392",{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},{"id":94,"title":95,"publisher":88,"authors":96,"publishedOn":97,"url":98},"b9550001-0001-4001-8001-000000000015","Low Doses of Sucralose Alter Fecal Microbiota in High-Fat Diet-Induced Obese Rats","Zhang M., Chen J., Yang M., Qian C., Liu Y., Qi Y., et al.","2021-11-01","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffnut.2021.787055",{"id":100,"title":101,"publisher":102,"authors":103,"publishedOn":104,"url":105},"b9550001-0001-4001-8001-000000000016","The impact of food additives, artificial sweeteners and domestic hygiene products on the human gut microbiome and its fibre fermentation capacity","Springer (European Journal of Nutrition)","Gerasimidis K., Bryden K., Chen X., et al.","2020-10-01","https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00394-019-02161-8",{"id":107,"title":108,"publisher":88,"authors":109,"publishedOn":110,"url":111},"b9550001-0001-4001-8001-000000000029","Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice","Bian X., Chi L., Gao B., Tu P., Ru H., Lu K.","2017-07-01","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphys.2017.00487",{"id":113,"title":114,"publisher":115,"authors":116,"publishedOn":117,"url":118},"b9550001-0001-4001-8001-000000000030","Effects of low-dose non-caloric sweetener consumption on gut microbiota in mice","MDPI (Nutrients)","Uebanso T., Ohnishi A., Kitayama R., et al.","2017-06-01","https:\u002F\u002Fdoi.org\u002F10.3390\u002Fnu9060560",{"id":64,"title":65,"publisher":66,"authors":67,"publishedOn":68,"url":69},{"risk":121,"explanation":125,"sources":126},{"slug":122,"label":123,"icon":124},"toxique-organes","Toxicité foie \u002F rein","skull","Des travaux suggèrent une stéatose hépatique, une inflammation du foie, une immunotoxicité sur les lymphocytes et des effets négatifs sur le système immunitaire.",[127,134,139,145,152],{"id":128,"title":129,"publisher":130,"authors":131,"publishedOn":132,"url":133},"b9550001-0001-4001-8001-000000000005","The dietary sweetener sucralose is a negative modulator of T cell-mediated responses","Nature","Zani F., Blagih J., Gruber T., et al.","2023-03-01","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41586-023-05801-6",{"id":135,"title":136,"publisher":88,"authors":137,"publishedOn":90,"url":138},"b9550001-0001-4001-8001-000000000014","Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3","Wu H. T., Lin C. H., Pai H. L., Chen Y. C., Cheng K. P., Kuo H. Y., et al.","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffnut.2022.823723",{"id":140,"title":141,"publisher":142,"authors":143,"publishedOn":104,"url":144},"b9550001-0001-4001-8001-000000000021","Sucralose causes non-selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8\u002FAPTX\u002FEID1 genes: An in vitro\u002Fin silico study","Wiley (CEPP)","Pasqualli T., E Chaves P. E., da Veiga Pereira L., et al.","https:\u002F\u002Fdoi.org\u002F10.1111\u002F1440-1681.13362",{"id":146,"title":147,"publisher":148,"authors":149,"publishedOn":150,"url":151},"b9550001-0001-4001-8001-000000000017","Maternal sucralose intake alters gut microbiota of offspring and exacerbates hepatic steatosis in adulthood","Taylor & Francis (Gut Microbes)","Dai X., Guo Z., Chen D., Li L., Song X., Liu T., et al.","2020-01-01","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F32228300\u002F",{"id":107,"title":108,"publisher":88,"authors":109,"publishedOn":110,"url":111},{"risk":154,"explanation":158,"sources":159},{"slug":155,"label":156,"icon":157},"maladies-cardiovasculaires","Maladies cardiovasculaires","cardiology","Des cohortes prospectives observent une association entre édulcorants de synthèse, dont le sucralose, et un risque cardiovasculaire accru.",[160,166,173],{"id":161,"title":162,"publisher":163,"authors":164,"publishedOn":33,"url":165},"b9550001-0001-4001-8001-000000000009","Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort","BMJ","Debras C., Chazelas E., Sellem L., Porcher R., Druesne-Pecollo N., Esseddik Y., et al.","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmj-2022-071204",{"id":167,"title":168,"publisher":169,"authors":170,"publishedOn":171,"url":172},"b9550001-0001-4001-8001-000000000018","Artificial sweeteners impair endothelial vascular reactivity: Preliminary results in rodents","NMCD","Risdon S., Meyer G., Marziou A., Riva C., Roustit M., Walther G.","2020-05-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.numecd.2020.01.014",{"id":174,"title":175,"publisher":176,"authors":177,"publishedOn":110,"url":178},"b9550001-0001-4001-8001-000000000031","Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies","CMAJ (via NIH\u002FPubMed)","Azad M. B., et al.","https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpubmed\u002F28716847",{"risk":180,"explanation":184,"sources":185},{"slug":181,"label":182,"icon":183},"cancer-suspecte","Cancérogène suspecté","oncology","Certaines études chez l'animal et des analyses épidémiologiques soulèvent des questions sur un risque cancérogène potentiel, bien que les avis réglementaires restent divergents.",[186,193,200],{"id":187,"title":188,"publisher":189,"authors":190,"publishedOn":191,"url":192},"b9550001-0001-4001-8001-000000000010","Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study","PLOS","Debras C., Chazelas E., Srour B., Druesne-Pecollo N., Esseddik Y., et al.","2022-03-24","https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pmed.1003950",{"id":194,"title":195,"publisher":196,"authors":197,"publishedOn":198,"url":199},"b9550001-0001-4001-8001-000000000002","Statement on the validity of the conclusions of a mouse carcinogenicity study on sucralose (E 955) performed by the Ramazzini Institute","EFSA","EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)","2017-05-01","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2017.4784",{"id":201,"title":202,"publisher":203,"authors":204,"publishedOn":205,"url":206},"b9550001-0001-4001-8001-000000000032","Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice","Taylor & Francis (IJOEH)","Soffritti M., Padovani M., Tibaldi E., et al.","2016-01-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.fct.2017.05.047",{"risk":208,"explanation":212,"sources":213},{"slug":209,"label":210,"icon":211},"troubles-metaboliques","Troubles du métabolisme","metabolism","La consommation régulière pourrait favoriser la prise de poids, l'inflammation systémique, la bioaccumulation dans les tissus adipeux et des altérations métaboliques chez les nouveau-nés en cas d'exposition pendant la grossesse.",[214,221,228,234,241,247],{"id":215,"title":216,"publisher":217,"authors":218,"publishedOn":219,"url":220},"b9550001-0001-4001-8001-000000000006","Newborns from Mothers Who Intensely Consumed Sucralose during Pregnancy Are Heavier and Exhibit Markers of Metabolic Alteration and Low-Grade Systemic Inflammation: A Cross-Sectional, Prospective Study","MDPI (Biomedicines)","Aguayo-Guerrero JA., Méndez-García LA., Manjarrez-Reyna AN., et al.","2023-02-21","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F36979631\u002F",{"id":222,"title":223,"publisher":224,"authors":225,"publishedOn":226,"url":227},"b9550001-0001-4001-8001-000000000007","Biological Assessment of Stevioside and Sucralose as Sucrose Substitutes for Diabetics on STZ-Induced Diabetes in Rats","MDPI (Molecules)","Barakat H., Al-Roug K., Algonaiman R., et al.","2023-01-01","https:\u002F\u002Fdoi.org\u002F10.3390\u002Fmolecules28030940",{"id":229,"title":230,"publisher":231,"authors":232,"publishedOn":104,"url":233},"b9550001-0001-4001-8001-000000000022","Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells","Nature (International Journal of Obesity)","Azad M. B., Archibald A., Tomczyk M. M., et al.","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41366-020-0575-x",{"id":235,"title":236,"publisher":237,"authors":238,"publishedOn":239,"url":240},"b9550001-0001-4001-8001-000000000019","Consumption of Diet Soda Sweetened with Sucralose and Acesulfame-Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity","Wiley (Molecular Nutrition & Food Research)","Sylvetsky A. C., Sen S., Merkel P., et al.","2020-06-01","https:\u002F\u002Fdoi.org\u002F10.1002\u002Fmnfr.201901166",{"id":242,"title":243,"publisher":88,"authors":244,"publishedOn":245,"url":246},"b9550001-0001-4001-8001-000000000023","Maternal exposure to non-nutritive sweeteners impacts progeny's metabolism and microbiome","Olivier-Van Stichelen S., Rother K. I., Hanover J. A.","2019-01-01","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffmicb.2019.01360",{"id":248,"title":249,"publisher":250,"authors":251,"publishedOn":252,"url":253},"b9550001-0001-4001-8001-000000000027","Intestinal metabolism and bioaccumulation of sucralose in adipose tissue in the rat","Taylor & Francis (JTEH)","Bornemann V., Werness S. C., Buslinger L., Schiffman S. S.","2018-08-01","https:\u002F\u002Fdoi.org\u002F10.1080\u002F15287394.2018.1502560",{"risk":255,"explanation":259,"sources":260},{"slug":256,"label":257,"icon":258},"perturbateur-endocrinien","Perturbateur endocrinien","science","Des études chez l'animal indiquent une possible perturbation de l'axe thyroïdien selon le vecteur de saveur sucrée utilisé.",[261],{"id":262,"title":263,"publisher":102,"authors":264,"publishedOn":265,"url":266},"b9550001-0001-4001-8001-000000000025","Type of sweet flavour carrier affects thyroid axis activity in male rats","Pałkowska-Goździk E., Bigos A., Rosołowska-Huszcz D.","2018-03-01","https:\u002F\u002Fdoi.org\u002F10.1007\u002Fs00394-016-1367-x",[268,275,276,277,278,279,280,281,282,283,284,285,286,287,288,289,290,291,292,293,294,295,296,297,298,304,305,306,307,308,309,316,317,318],{"id":269,"title":270,"publisher":271,"authors":272,"publishedOn":273,"url":274},"b9550001-0001-4001-8001-000000000001","Aspartame and Other Sweeteners in Food","FDA","U.S. Food and Drug Administration","2024-01-01","https:\u002F\u002Fwww.fda.gov\u002Ffood\u002Ffood-additives-petitions\u002Faspartame-and-other-sweeteners-food",{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},{"id":128,"title":129,"publisher":130,"authors":131,"publishedOn":132,"url":133},{"id":215,"title":216,"publisher":217,"authors":218,"publishedOn":219,"url":220},{"id":222,"title":223,"publisher":224,"authors":225,"publishedOn":226,"url":227},{"id":161,"title":162,"publisher":163,"authors":164,"publishedOn":33,"url":165},{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},{"id":187,"title":188,"publisher":189,"authors":190,"publishedOn":191,"url":192},{"id":86,"title":87,"publisher":88,"authors":89,"publishedOn":90,"url":91},{"id":135,"title":136,"publisher":88,"authors":137,"publishedOn":90,"url":138},{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},{"id":94,"title":95,"publisher":88,"authors":96,"publishedOn":97,"url":98},{"id":229,"title":230,"publisher":231,"authors":232,"publishedOn":104,"url":233},{"id":140,"title":141,"publisher":142,"authors":143,"publishedOn":104,"url":144},{"id":100,"title":101,"publisher":102,"authors":103,"publishedOn":104,"url":105},{"id":235,"title":236,"publisher":237,"authors":238,"publishedOn":239,"url":240},{"id":167,"title":168,"publisher":169,"authors":170,"publishedOn":171,"url":172},{"id":43,"title":44,"publisher":45,"authors":46,"publishedOn":47,"url":48},{"id":146,"title":147,"publisher":148,"authors":149,"publishedOn":150,"url":151},{"id":242,"title":243,"publisher":88,"authors":244,"publishedOn":245,"url":246},{"id":50,"title":51,"publisher":52,"authors":53,"publishedOn":54,"url":55},{"id":248,"title":249,"publisher":250,"authors":251,"publishedOn":252,"url":253},{"id":262,"title":263,"publisher":102,"authors":264,"publishedOn":265,"url":266},{"id":57,"title":58,"publisher":59,"authors":60,"publishedOn":61,"url":62},{"id":299,"title":300,"publisher":301,"authors":302,"publishedOn":110,"url":303},"b9550001-0001-4001-8001-000000000028","Critical review of the current literature on the safety of sucralose","ScienceDirect (FCT)","Magnuson B. A., Roberts A., Nestmann E. R.","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F28558975\u002F",{"id":107,"title":108,"publisher":88,"authors":109,"publishedOn":110,"url":111},{"id":174,"title":175,"publisher":176,"authors":177,"publishedOn":110,"url":178},{"id":113,"title":114,"publisher":115,"authors":116,"publishedOn":117,"url":118},{"id":194,"title":195,"publisher":196,"authors":197,"publishedOn":198,"url":199},{"id":201,"title":202,"publisher":203,"authors":204,"publishedOn":205,"url":206},{"id":310,"title":311,"publisher":312,"authors":313,"publishedOn":314,"url":315},"b9550001-0001-4001-8001-000000000003","Avis du 19 novembre 2014 révisé le 9 janvier 2015 relatif à l'évaluation des bénéfices et des risques nutritionnels des édulcorants intenses","ANSES","Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail","2015-01-09","https:\u002F\u002Fwww.anses.fr\u002Ffr\u002Fsystem\u002Ffiles\u002FNUT2011sa0161Ra.pdf",{"id":64,"title":65,"publisher":66,"authors":67,"publishedOn":68,"url":69},{"id":71,"title":72,"publisher":73,"authors":74,"publishedOn":75,"url":76},{"id":319,"title":320,"publisher":321,"authors":322,"publishedOn":323,"url":324},"b9550001-0001-4001-8001-000000000004","Studies on glucose homeostasis in healthy humans and diabetic volunteers. In: Opinion of the Scientific Committee on Food on Sucralose","Commission Européenne","Scientific Committee on Food (SCF)","2000-09-07","https:\u002F\u002Ffood.ec.europa.eu\u002Fsystem\u002Ffiles\u002F2020-12\u002Fsci-com_scf_out68_en.pdf",1789814238359]