[{"data":1,"prerenderedAt":209},["ShallowReactive",2],{"additive-sources:e950":3},{"articlePublished":4,"id":5,"code":6,"name":7,"slug":8,"type":9,"rating":10,"summary":11,"typeDescription":12,"risks":13,"bibliography":188,"hasDetail":4},true,"4d4caced-195f-479c-a6e7-e20e541cb3a2","E950","Acésulfame potassium, Acésulfame K","e950","Édulcorant",3,"Cet édulcorant artificiel serait associé à une augmentation du risque de cancers, de maladies cardiovasculaires, de diabète de type 2 et d'inflammation chronique au niveau du tube digestif. Plusieurs études soulignent qu'au lieu d'aider à réguler le poids, sa consommation régulière pourrait perturber le métabolisme et augmenter les risques de surpoids.","Permet de remplacer le sucre en donnant une saveur sucrée au produit, sans calories.",[14,42,76,114,128,162],{"risk":15,"explanation":19,"sources":20},{"slug":16,"label":17,"icon":18},"cancer-suspecte","Cancérogène suspecté","oncology","Des études épidémiologiques récentes ont observé une association entre la consommation d'édulcorants artificiels, dont l'acésulfame-K, et un risque accru de certains cancers. Les mécanismes restent débattus et les avis des agences sanitaires divergent encore sur le niveau de preuve.",[21,28,35],{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},"b9500001-0001-4001-8001-000000000004","Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study","PLoS Medicine","Debras C., Chazelas E., Srour B., Druesne-Pecollo N., Esseddik Y., Szabo de Edelenyi F., Agaesse C., De Sa A., Lutchia R., Gigandet S., Huybrechts I., Julia C., Kesse-Guyot E., Allès B., Andreeva VA., Galan P., Hercberg S., Deschasaux-Tanguy M., Touvier M.","2022-03-24","https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pmed.1003950",{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},"b9500001-0001-4001-8001-000000000018","Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin","Drug and Chemical Toxicology","Bandyopadhyay A., Ghoshal S., Mukherjee A.","2008-01-01","https:\u002F\u002Fdoi.org\u002F10.1080\u002F01480540802390270",{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},"b9500001-0001-4001-8001-000000000020","In vivo cytogenetic studies on mice exposed to acesulfame-K - a non-nutritive sweetener","Food and Chemical Toxicology","Mukherjee A., Chakrabarti J.","1997-01-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fs0278-6915(97)85469-5",{"risk":43,"explanation":47,"sources":48},{"slug":44,"label":45,"icon":46},"maladies-cardiovasculaires","Maladies cardiovasculaires","cardiology","Des cohortes à grande échelle rapportent une association entre édulcorants de synthèse et un risque cardiovasculaire plus élevé. L'OMS a recommandé en 2023 de ne pas utiliser les édulcorants pour le contrôle du poids ou la prévention des maladies non transmissibles.",[49,55,62,69],{"id":50,"title":51,"publisher":52,"authors":52,"publishedOn":53,"url":54},"b9500001-0001-4001-8001-000000000001","Aspartame and Other Sweeteners in Food","U.S. Food and Drug Administration (FDA)","2024-01-01","https:\u002F\u002Fwww.fda.gov\u002Ffood\u002Ffood-additives-petitions\u002Faspartame-and-other-sweeteners-food",{"id":56,"title":57,"publisher":58,"authors":59,"publishedOn":60,"url":61},"b9500001-0001-4001-8001-000000000003","Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort","BMJ (British Medical Journal)","Debras C., Chazelas E., Sellem L., Porcher R., Druesne-Pecollo N., Esseddik Y., et al.","2022-01-01","https:\u002F\u002Fdoi.org\u002F10.1136\u002Fbmj-2022-071204",{"id":63,"title":64,"publisher":65,"authors":66,"publishedOn":67,"url":68},"b9500001-0001-4001-8001-000000000008","Artificial sweeteners impair endothelial vascular reactivity: Preliminary results in rodents","Nutrition, Metabolism and Cardiovascular Diseases","Risdon S., Meyer G., Marziou A., Riva C., Roustit M., Walther G.","2020-01-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.numecd.2020.01.014",{"id":70,"title":71,"publisher":72,"authors":73,"publishedOn":74,"url":75},"b9500001-0001-4001-8001-000000000017","Avis du 19 novembre 2014 révisé le 9 janvier 2015 relatif à l'évaluation des bénéfices et des risques nutritionnels des édulcorants intenses (Saisine n°2011-SA-0161)","ANSES","Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)","2015-01-09","https:\u002F\u002Fwww.anses.fr\u002Ffr\u002Fsystem\u002Ffiles\u002FNUT2011sa0161Ra.pdf",{"risk":77,"explanation":81,"sources":82},{"slug":78,"label":79,"icon":80},"diabete-type-2","Diabète de type 2","bloodtype","Malgré l'absence de calories, certains travaux suggèrent que les édulcorants intensifs pourraient perturber la régulation glycémique et le microbiote intestinal, avec un risque métabolique accru à long terme.",[83,90,96,102,108],{"id":84,"title":85,"publisher":86,"authors":87,"publishedOn":88,"url":89},"b9500001-0001-4001-8001-000000000002","Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort","Diabetes Care","Debras C., Deschasaux-Tanguy M., Chazelas E., Sellem L., Druesne-Pecollo N., Esseddik Y., Szabo de Edelenyi F., Agaesse C., De Sa A., Lutchia R., Julia C., Kesse-Guyot E., Allès B., Galan P., Hercberg S., Huybrechts I., Cosson E., Tatulashvili S., Srour B., Touvier M.","2023-09-01","https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpmc\u002Farticles\u002FPMC10465821\u002F",{"id":91,"title":92,"publisher":93,"authors":94,"publishedOn":60,"url":95},"b9500001-0001-4001-8001-000000000005","Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats","JCI Insight","Tsan L., Chometton S., Hayes A. M., Klug M. E., Zuo Y., Sun S., et al.","https:\u002F\u002Fdoi.org\u002F10.1172\u002Fjci.insight.157714",{"id":97,"title":98,"publisher":99,"authors":100,"publishedOn":60,"url":101},"b9500001-0001-4001-8001-000000000006","Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance","Cell","Suez J., Cohen Y., Valdés-Mas R., Mor U., Dori-Bachash M., Federici S., et al.","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F35987213\u002F",{"id":103,"title":104,"publisher":105,"authors":106,"publishedOn":67,"url":107},"b9500001-0001-4001-8001-000000000009","Consumption of the artificial sweetener acesulfame potassium throughout pregnancy induces glucose intolerance and adipose tissue dysfunction in mice","The Journal of Nutrition","Plows J. F., Morton-Jones J., Bridge-Comer P. E., Ponnampalam A., Stanley J. L., Vickers M. H., Reynolds C. M.","https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjn\u002Fnxaa106",{"id":109,"title":110,"publisher":111,"authors":112,"publishedOn":67,"url":113},"b9500001-0001-4001-8001-000000000010","Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells","International Journal of Obesity","Azad M. B., Archibald A., Tomczyk M. M., Head A., Cheung K. G., de Souza R. J., et al.","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41366-020-0575-x",{"risk":115,"explanation":119,"sources":120},{"slug":116,"label":117,"icon":118},"inflammation-digestive","Inflammation digestive","gastroenterology","Des travaux chez l'animal et chez l'humain suggèrent que l'acésulfame-K pourrait favoriser une inflammation de la muqueuse intestinale et une dysbiose.",[121],{"id":122,"title":123,"publisher":124,"authors":125,"publishedOn":126,"url":127},"b9500001-0001-4001-8001-000000000007","Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa","Journal of Gastroenterology and Hepatology","Hanawa Y., Higashiyama M., Kurihara C., Tanemoto R., Ito S., Mizoguchi A., et al.","2021-01-01","https:\u002F\u002Fdoi.org\u002F10.1111\u002Fjgh.15654",{"risk":129,"explanation":133,"sources":134},{"slug":130,"label":131,"icon":132},"microbiote","Perturbation du microbiote","biotech","Plusieurs études montrent que les édulcorants sans calories, dont l'acésulfame-K, modifient la composition du microbiote intestinal et peuvent altérer la tolérance au glucose.",[135,136,143,150,155],{"id":97,"title":98,"publisher":99,"authors":100,"publishedOn":60,"url":101},{"id":137,"title":138,"publisher":139,"authors":140,"publishedOn":141,"url":142},"b9500001-0001-4001-8001-000000000012","Maternal exposure to non-nutritive sweeteners impacts progeny's metabolism and microbiome","Frontiers in Microbiology","Olivier-Van Stichelen S., Rother K. I., Hanover J. A.","2019-01-01","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffmicb.2019.01360",{"id":144,"title":145,"publisher":146,"authors":147,"publishedOn":148,"url":149},"b9500001-0001-4001-8001-000000000015","Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice","Frontiers in Physiology","Bian X., Chi L., Gao B., Tu P., Ru H., Lu K.","2017-01-01","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffphys.2017.00487",{"id":151,"title":152,"publisher":153,"authors":147,"publishedOn":148,"url":154},"b9500001-0001-4001-8001-000000000014","The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice","PLoS One","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F28594855\u002F",{"id":156,"title":157,"publisher":158,"authors":159,"publishedOn":160,"url":161},"b9500001-0001-4001-8001-000000000016","Artificial sweeteners induce glucose intolerance by altering the gut microbiota","Nature","Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss CA., Maza O., et al.","2014-01-01","https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F25231862\u002F",{"risk":163,"explanation":167,"sources":168},{"slug":164,"label":165,"icon":166},"troubles-metaboliques","Troubles du métabolisme","metabolism","Des études épidémiologiques et expérimentales rapportent une association entre édulcorants artificiels et prise de poids, adiposité ou perturbations métaboliques, sans bénéfice démontré sur le contrôle du poids.",[169,176,182],{"id":170,"title":171,"publisher":172,"authors":173,"publishedOn":174,"url":175},"b9500001-0001-4001-8001-000000000013","Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, double-blind, placebo-controlled trial","Nutrition","Lertrit A., Srimachai S., Saetung S., Chanprasertyothin S., Chailurkit L. O., Areevut C., et al.","2018-01-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.nut.2018.04.001",{"id":177,"title":178,"publisher":153,"authors":179,"publishedOn":180,"url":181},"b9500001-0001-4001-8001-000000000011","Relationship between Research Outcomes and Risk of Bias, Study Sponsorship, and Author Financial Conflicts of Interest in Reviews of the Effects of Artificially Sweetened Beverages on Weight Outcomes: A Systematic Review of Reviews","Mandrioli D., Kearns CE., Bero LA.","2016-09-08","https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpmc\u002Farticles\u002FPMC5015869\u002F",{"id":183,"title":184,"publisher":185,"authors":186,"publishedOn":33,"url":187},"b9500001-0001-4001-8001-000000000019","Fueling the Obesity Epidemic? Artificially Sweetened Beverage Use and Long-term Weight Gain","Obesity","Fowler S.P., Williams K., Resendez R.G., Hunt K.J., Hazuda H.P., Stern M.P.","https:\u002F\u002Fdoi.org\u002F10.1038\u002Foby.2008.284",[189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208],{"id":50,"title":51,"publisher":52,"authors":52,"publishedOn":53,"url":54},{"id":84,"title":85,"publisher":86,"authors":87,"publishedOn":88,"url":89},{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},{"id":56,"title":57,"publisher":58,"authors":59,"publishedOn":60,"url":61},{"id":91,"title":92,"publisher":93,"authors":94,"publishedOn":60,"url":95},{"id":97,"title":98,"publisher":99,"authors":100,"publishedOn":60,"url":101},{"id":122,"title":123,"publisher":124,"authors":125,"publishedOn":126,"url":127},{"id":63,"title":64,"publisher":65,"authors":66,"publishedOn":67,"url":68},{"id":103,"title":104,"publisher":105,"authors":106,"publishedOn":67,"url":107},{"id":109,"title":110,"publisher":111,"authors":112,"publishedOn":67,"url":113},{"id":137,"title":138,"publisher":139,"authors":140,"publishedOn":141,"url":142},{"id":170,"title":171,"publisher":172,"authors":173,"publishedOn":174,"url":175},{"id":144,"title":145,"publisher":146,"authors":147,"publishedOn":148,"url":149},{"id":151,"title":152,"publisher":153,"authors":147,"publishedOn":148,"url":154},{"id":177,"title":178,"publisher":153,"authors":179,"publishedOn":180,"url":181},{"id":70,"title":71,"publisher":72,"authors":73,"publishedOn":74,"url":75},{"id":156,"title":157,"publisher":158,"authors":159,"publishedOn":160,"url":161},{"id":183,"title":184,"publisher":185,"authors":186,"publishedOn":33,"url":187},{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},1789814238151]