[{"data":1,"prerenderedAt":147},["ShallowReactive",2],{"additive-detail:e551":3},{"articlePublished":4,"id":5,"code":6,"name":7,"slug":8,"type":9,"rating":10,"summary":11,"typeDescription":12,"risks":13,"bibliography":124,"hasDetail":4},true,"060d0f44-5804-4810-bda4-68eacb7d7912","E551","Dioxyde de silicium (amorphe), Silice (amorphe)","e551","Antiagglomérant",3,"Le dioxyde de silicium (E551) est autorisé comme antiagglomérant : l'EFSA (2018, 2024) et la FDA ne concluent pas à un risque aux usages déclarés. Des études expérimentales soulèvent toutefois des signaux de prudence liés à la fraction nanoparticulaire : présence de nanosilice après digestion, effets possibles sur le microbiote, l'inflammation intestinale, la tolérance orale aux antigènes alimentaires, ainsi que des lésions rénales et hépatiques chez l'animal. L'évaluation du risque oral reste compliquée par l'hétérogénéité des matériaux et des protocoles.","Antiagglomérant minéral (silice amorphe synthétique) empêchant les poudres de s'agglutiner. Les particules constitutives sont en partie nanométriques.",[14,62,83,104],{"risk":15,"explanation":19,"sources":20},{"slug":16,"label":17,"icon":18},"toxique-organes","Toxicité foie \u002F rein","skull","Chez la souris, une exposition orale chronique à de la silice amorphe synthétique (NM-200) a été associée à des dépôts de silice, des anomalies histologiques rénales et une inflammation hépatique. D'autres travaux (ex. Tassinari) rapportent une accumulation et des effets sur foie\u002Frate selon la voie et le matériau. Ces signaux contrastent avec les conclusions réglementaires aux doses alimentaires actuelles, d'où le débat sur la fraction nano.",[21,28,35,42,49,56],{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},"b5510001-0001-4001-8001-000000000002","Re-evaluation of silicon dioxide (E 551) as a food additive in foods for infants below 16 weeks of age and follow-up of its re-evaluation as a food additive for uses in foods for all population groups","EFSA Journal","EFSA Panel on Food Additives and Flavourings (FAF)","2024-10-10","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2024.8880",{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},"b5510001-0001-4001-8001-000000000009","A toxicological profile of silica nanoparticles","Toxicology Research","Liu J. Y., Sayes C. M.","2022-07-16","https:\u002F\u002Fdoi.org\u002F10.1093\u002Ftoxres\u002Ftfac038",{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},"b5510001-0001-4001-8001-000000000011","Issues currently complicating the risk assessment of synthetic amorphous silica (SAS) nanoparticles after oral exposure","Nanotoxicology","Brand W., et al.","2021-07-01","https:\u002F\u002Fdoi.org\u002F10.1080\u002F17435390.2021.1931724",{"id":43,"title":44,"publisher":45,"authors":46,"publishedOn":47,"url":48},"b5510001-0001-4001-8001-000000000014","Hazard identification of pyrogenic synthetic amorphous silica (NM-203) after sub-chronic oral exposure in rat: A multitarget approach","Food and Chemical Toxicology","Tassinari R., Cubadda F., Moracci G., Aureli F., et al.","2020-03-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.fct.2020.111168",{"id":50,"title":51,"publisher":52,"authors":53,"publishedOn":54,"url":55},"b5510001-0001-4001-8001-000000000006","Chronic Oral Exposure to Synthetic Amorphous Silica (NM-200) Results in Renal and Liver Lesions in Mice","Kidney International Reports","Boudard D., Aureli F., Laurent B., Sturm N., Raggi A., et al.","2019-10-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.ekir.2019.06.007",{"id":57,"title":58,"publisher":24,"authors":59,"publishedOn":60,"url":61},"b5510001-0001-4001-8001-000000000001","Re-evaluation of silicon dioxide (E 551) as a food additive","EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)","2018-01-17","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2018.5088",{"risk":63,"explanation":67,"sources":68},{"slug":64,"label":65,"icon":66},"microbiote","Perturbation du microbiote","biotech","Des revues récentes décrivent des interactions entre nanoparticules de silice amorphe et microbiote intestinal, avec des implications possibles pour l'immunité et la barrière intestinale. Ces effets restent surtout documentés en expérimental et ne remettent pas seuls en cause l'autorisation réglementaire.",[69,76],{"id":70,"title":71,"publisher":72,"authors":73,"publishedOn":74,"url":75},"b5510001-0001-4001-8001-000000000007","Amorphous silica nanoparticles and the human gut microbiota: a relationship with multiple implications","Journal of Nanobiotechnology","Bianchi M. G., Chiu M., Taurino G., Bergamaschi E., et al.","2024-02-01","https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs12951-024-02305-x",{"id":77,"title":78,"publisher":79,"authors":80,"publishedOn":81,"url":82},"b5510001-0001-4001-8001-000000000013","Ultra-processed foods and food additives in gut health and disease","Nature Reviews Gastroenterology & Hepatology","Whelan K., et al.","2024-01-01","https:\u002F\u002Fdoi.org\u002F10.1038\u002Fs41575-024-00893-5",{"risk":84,"explanation":88,"sources":89},{"slug":85,"label":86,"icon":87},"inflammation-digestive","Inflammation digestive","gastroenterology","Chez l'animal, l'ingestion de nanoparticules de silice de petite taille peut aggraver une inflammation intestinale. Des travaux in vitro montrent aussi que de la nanosilice peut subsister après digestion d'aliments contenant de l'E551, ce qui entretient l'exposition locale du tube digestif.",[90,97],{"id":91,"title":92,"publisher":93,"authors":94,"publishedOn":95,"url":96},"b5510001-0001-4001-8001-000000000010","Oral intake of silica nanoparticles exacerbates intestinal inflammation","Biochemical and Biophysical Research Communications","Ogawa T., Okumura R., Nagano K., Minemura T., Izumi M., et al.","2021-01-01","https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.bbrc.2020.11.047",{"id":98,"title":99,"publisher":100,"authors":101,"publishedOn":102,"url":103},"b5510001-0001-4001-8001-000000000012","Presence of Nano-Sized Silica during In Vitro Digestion of Foods Containing Silica as a Food Additive","ACS Nano","Peters R., Kramer E., Oomen A. G., Rivera Z. E., et al.","2012-03-27","https:\u002F\u002Fdoi.org\u002F10.1021\u002Fnn204728k",{"risk":105,"explanation":109,"sources":110},{"slug":106,"label":107,"icon":108},"allergies","Allergies","allergy","Une exposition orale chronique à l'E551 à dose pertinente pour l'humain a bloqué l'induction de la tolérance orale à un antigène alimentaire chez la souris et soulevé des questions sur les sensibilités alimentaires. Le lien chez l'humain n'est pas établi, mais le signal immunitaire est jugé pertinent à surveiller.",[111,118],{"id":112,"title":113,"publisher":114,"authors":115,"publishedOn":116,"url":117},"b5510001-0001-4001-8001-000000000008","Evaluating the Effects of Chronic Oral Exposure to the Food Additive Silicon Dioxide on Oral Tolerance Induction and Food Sensitivities in Mice","Environmental Health Perspectives","Lamas B., Martins Breyner N., Gaultier E., Cartier C., et al.","2024-02-21","https:\u002F\u002Fdoi.org\u002F10.1289\u002FEHP12758",{"id":119,"title":120,"publisher":24,"authors":121,"publishedOn":122,"url":123},"b5510001-0001-4001-8001-000000000003","Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health","EFSA Scientific Committee","2021-08-03","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2021.6768",[125,126,127,128,134,135,136,137,141,142,143,144,145,146],{"id":22,"title":23,"publisher":24,"authors":25,"publishedOn":26,"url":27},{"id":112,"title":113,"publisher":114,"authors":115,"publishedOn":116,"url":117},{"id":70,"title":71,"publisher":72,"authors":73,"publishedOn":74,"url":75},{"id":129,"title":130,"publisher":131,"authors":132,"publishedOn":81,"url":133},"b5510001-0001-4001-8001-000000000005","Silicon dioxide (21 CFR 172.480)","U.S. Food and Drug Administration (FDA)","U.S. Food and Drug Administration","https:\u002F\u002Fwww.ecfr.gov\u002Fcurrent\u002Ftitle-21\u002Fchapter-I\u002Fsubchapter-B\u002Fpart-172\u002Fsubpart-E\u002Fsection-172.480",{"id":77,"title":78,"publisher":79,"authors":80,"publishedOn":81,"url":82},{"id":29,"title":30,"publisher":31,"authors":32,"publishedOn":33,"url":34},{"id":119,"title":120,"publisher":24,"authors":121,"publishedOn":122,"url":123},{"id":138,"title":139,"publisher":24,"authors":121,"publishedOn":122,"url":140},"b5510001-0001-4001-8001-000000000004","Guidance on technical requirements for regulated food and feed product applications to establish the presence of small particles including nanoparticles","https:\u002F\u002Fdoi.org\u002F10.2903\u002Fj.efsa.2021.6769",{"id":36,"title":37,"publisher":38,"authors":39,"publishedOn":40,"url":41},{"id":91,"title":92,"publisher":93,"authors":94,"publishedOn":95,"url":96},{"id":43,"title":44,"publisher":45,"authors":46,"publishedOn":47,"url":48},{"id":50,"title":51,"publisher":52,"authors":53,"publishedOn":54,"url":55},{"id":57,"title":58,"publisher":24,"authors":59,"publishedOn":60,"url":61},{"id":98,"title":99,"publisher":100,"authors":101,"publishedOn":102,"url":103},1789814238192]